| 摘要 |
PURPOSE:To obtain a compound useful as a raw material for dobutamine hydrochloride which is a cardiotonicum in short process and high yield without discharging a substance which causes pollution, by hydrogenating 4-(4'- hydroxyphenyl)-2-butanoneoxime. CONSTITUTION:4-(4'-Hydroxyphenyl)-2-butaneoxime is dissolved in an organic solvent such as methanol and reduced with hydrogen in the presence of a hydro genation catalyst (e.g. Pd or Pt) to provide the aimed compound. The reaction is carried out in atmospheric pressure or higher, preferably in atmospheric pressure - 60atm. pressure. The catalyst is used in an amount of 0.5-30wt.%, preferably 1-10wt.% based on the oxime. The oxime which is a starting mate rial is synthesized from the reaction of 4-(4'-hydroxyphenyl)-2-butanone with hydroxylamine. |
