| 摘要 |
PURPOSE:To produce mevalonic acid in high efficiency by fermentation process, by culturing a specific microbial strain belonging to Saccharomycopsis or a variant of said microbial strain in a nutrient medium. CONSTITUTION:Saccharomycopsis fibuligera IFO 0107, 0103, 0104, 0105, 0106, 0109, 0111, 1665, 1711, 1745, AHR 4113, IAM 4247, OUT 6071, HUT 7234, ATCC 2080, 2082, 2088, 9947, 20145, 24945, 44872, 46252, 46253, 46949, 52921, NRRL Y-1060, Y-1064, Y-2385, Y-7061, Y-7221, Y-7324, Y-7464, DSM 70554 and their variants, preferably IFO 0107 is inoculated in a medium containing carbon source, organic nitrogen source, nonionic surfactant and inorganic salts and cultured at 20-40 deg.C, preferably 25-35 deg.C while adding a substrate in a manner to keep the carbon source concentration in the culture liquid within a specific range. The objective mevalonic acid can be produced by the process. |
