发明名称 PHOSPHOLIPASE A2-RESISTANT LIPOSOMES
摘要 A method to inhibit phospholipase A2-type hydrolytic degradation of liposome membranes is disclosed comprising forming a liposome having a bilayer membrane comprising (i) between about 67.5-85 mol-% of a phospholipid of formula (I), and (ii) between about 15.0-32.5 mol-% of a lysophospholipid of formula (II), wherein R2, R1 and R3 are individually (C10-C30) alkanoyl groups including from about 0-4 double bonds.
申请公布号 WO8806439(A2) 申请公布日期 1988.09.07
申请号 WO1988US00508 申请日期 1988.02.19
申请人 REGENTS OF THE UNIVERSITY OF MINNESOTA 发明人 BAUMANN, WOLFGANG, J.
分类号 A61K9/127 主分类号 A61K9/127
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