DNA FRAGMENTS ENCODING FOR AN IMMUNOGENIC PEPTIDE CAPABLE OF INDUCING IN VIVO SYNTHESIS OF ANTI-POLIO VIRUS ANTIBODIES

摘要

1. Recombinant vector, particularly of the phage of plasmid type, characterized by the fact that it contains an insert consisting substantially of a DNA fragment coming from a cDNA corresponding to the RNA of a poliovirus, possessing up to 1.2 kilopairs of bases and containing a nucleotide sequence coding for the poliovirus VP1 protein or for the part of this protein which codes for that or those of the antigenic determinants which can be considered as essentially responsible for the immunogenicity and immunological specificity of the poliovirus VP1 protein, i.e. the capacity of the protein or of the part of this protein to form antigen-antibody complexes or mono or polyclonal neutralizing sera, prepared by injection into an animal of the whole poliovirus fixed with formol (serum of D specificity).