| 摘要 |
<p>A novel thiazolidine derivative of general formula: <CHEM> [wherein R represents a group of general formula: G-E-D-B-A- (wherein A represents single bond, alkylene group of from 1 to 6 carbon atom(s), alkenylene group of from 2 to 6 carbon atoms, a group of general formula: <CHEM> or saturated hydrocarbon ring of from 4 to 7 carbon atoms or single heterocyclic ring. Y represents alkylene group of from 1 to 4 carbon atom(s) or alkenylene group of from 2 to 4 carbon atoms. B represents single bond or alkylene group of from 1 to 6 carbon atom(s). D represents single bond, oxygen atom, carbonyl group or a group of general formula: <CHEM> R<1> represents hydrogen atom, alkyl group of from 1 to 4 carbon atom(s), phenyl group or benzyl group. E represents single bond, alkylene group of from 1 to 8 carbon atom(s) or alkylene group of from 1 to 8 carbon atom(s) substituted by phenyl group or benzyl group. G represents carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three of alkyl group of from 1 to 6 carbon atom(s), alkoxy group of from 1 to 6 carbon atom(s), halogen atom, trifluoromethyl group or nitro group.) With the proviso that, A and B do not represent mono-bonds at the same time.] possess inhibitory activity on prolyl endopeptidase, and therefore be useful for treating and/or preventing agent for amnesia.</p> |
