| 摘要 |
PURPOSE:To obtain an amino acid decarboxylation product useful as medicines in high purity and concentration, by adding immobilized amino acid decarboxylate to a raw material amino acid and reacting both within a suitable action pH region. CONSTITUTION:Immobilized particles of amino acid decarboxylase are introduced into a reaction vessel 5 and held therein and a raw material solution 1 of an amino acid, such as dibasic amino acid, is added through a raw material transfer pipe 3 and reacted until the pH attains <=6.5 which is an enzymic suitable action pH range. The raw material is successively added so as to attain the total concentration of a monobasic acid which is a reaction product substance and raw material amino acids attains >=1wt.%. A slurry of the raw material amino acid in a concentration corresponding to the concentration of the product substance is then fed by a raw material transfer pump 4 drivably connected to a pH sensor 8 and pH automatic regulator 9 and a reaction solution 6 in an equal volume is taken out by a reaction solution transfer pipe 10 to carry out continuous operation. The resultant reaction solution is subsequently passed through a reaction solution concentrator 11 and dryer 13 to recover a monobasic amino acid which is a dried product 15.
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