ADRIAMYCIN OR DAUNOMYCIN COMPOSITION HAVING INCREASED ACTIVITY AND DECREASED TOXICITY

摘要

PCT No. PCT/JP83/00457 Sec. 371 Date Aug. 27, 1984 Sec. 102(e) Date Aug. 27, 1984 PCT Filed Dec. 27, 1983 PCT Pub. No. WO84/02527 PCT Pub. Date Jul. 5, 1984.The pressent invention provides a composition comprising adriamycin or daunomycin in mixture with one or more compounds selected from sulfite, acid sulfite, pyrosulfite, diothionite and sulfurous anhydride in order to reduce the toxicities of adriamycin or daunomycin and to increase the potency thereof and a method comprising administering said compounds in mixture with adriamycin or daunomycin. By the composition and method of the present invention the safe and effective treatment of various tumors with adriamycin and daunomycin, which have remarkably high potency, but also have serious side effects, will be provided.