| 发明名称 |
Ornithine derivatives and their use as methotrexate-resistant cell inhibitors |
| 摘要 |
Compounds having the structure <IMAGE> in which R is -CO-Ar-COOR1 where R1 is hydrogen or lower alkyl, and pharmaceutical compositions containing the same exhibiting high growth inhibitory activity against methotrexate resistant cells.
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| 申请公布号 |
US4767761(A) |
申请公布日期 |
1988.08.30 |
| 申请号 |
US19870117212 |
申请日期 |
1987.11.04 |
| 申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
ROSOWSKY, ANDRE;BADER HENRY |
| 分类号 |
A61K31/505;A61K31/519;A61P35/00;C07D475/08;(IPC1-7):A61K31/495 |
主分类号 |
A61K31/505 |
| 代理机构 |
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| 地址 |
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