发明名称 Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors
摘要 3-Hydroxyazabenzo[b]thiophene derivatives having optionally 2-aryl, 2-aralkyl, 2-alkyl or 2-alkenyl substituents were prepared by, among other methods, ring closure of an appropriately substituted benzylthio-alkoxycarbonyl-pyridine. These compounds are found to be useful in the treatment of pain, fever, inflammation, arthritic conditions, asthma, allergic disorders, skin diseases such as psoriasis and atopic eczema, cardiovascular disorders, inflammatory diseases and other leukotriene mediated diseases.
申请公布号 US4767766(A) 申请公布日期 1988.08.30
申请号 US19870008881 申请日期 1987.01.30
申请人 MERCK & CO., INC. 发明人 BAKER, ROBERT K.;RUPPRECHT, KATHLEEN M.;PESSOLANO, ARSENIO A.;DURETTE, PHILIPPE L.
分类号 C07D495/04;(IPC1-7):A61K31/435 主分类号 C07D495/04
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