| 摘要 |
PURPOSE:To obtain the titled compound useful as a precursor for gastric inhibitory agent acting on histamine H2-receptor antagonistic action, in high yield, by reacting a cyanoguanidine derivative with a diacetyl derivative in the presence of an easily handleable catalyst available at a low cost. CONSTITUTION:The objective compound of formula III can be produced by reacting a cyanoguanidine derivative of a formula I (R is lower alkyl) with a diacetyl derivative of formula II (X is Cl or Br) in the presence of an alkali metal hydroxide (e.g. potassium hydroxide) or an alkali metal carbonate (e.g. sodium carbonate). The reaction is carried out in a solvent such as methanol at -30-+50 deg.C for 10min-5hr, preferably at 0-10 deg.C for 30min-3hr. The amount of the solvent is 1-20pts. and that of the alkali metal hydroxide or alkali metal carbonate is 1-2 equivalent based on the compound of formula I.
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