| 摘要 |
NEW MATERIAL:The compound of formula I [R is 1-4C straight-chain, branched-chain, cyclic or cyclic-chain alkyl; X<1>-X<3> are H, halogen, 1-4C alkyl, 1-4C alkoxy, nitro, CF3, OH or t-butyldimethylsilyloxy; X<1>-X<3> are hot H at the same time]. EXAMPLE:3-{2-[N-benzyl-N-( 3,4-dichlorobenzyl)amino]ethoxycarbonyl}-5-isopro poxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-3,4-dihydropyrimidine. USE:A drug. A remedy for circulatory diseases. It is useful for the remedy of stenocardia (myocardial infraction), hypertension and cerebral circulation diseases. PREPARATION:The compound of formula I can be produced by dissolving a compound of formula II or formula III in an organic solvent, adding the solution to an organic solvent solution of phosgene, etc., in the presence of a base at <=0 deg.C and adding a solution of an N-substituted-ethanolamine derivative of formula IV to the reaction product at room temperature.
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