| 摘要 |
The present invention relates to novel monoC(26,27) and diepoxide C(14,15;26,27) derivatives of LL-F28249 alpha , beta , epsilon , zeta , theta and @ compounds. The LL-F28249 compounds (collectively) are isolates from the fermentation broth of Streotomyces cyaneogriseus subspecies noncyanogenus having deposit accession number NRRL15773. The compounds of this present invention are derived by regioselective epoxidation of 5,23-0,0-bis-silylated LL-F28249 compounds at low temperature, followed by desilylation. These novel compounds have anthelmintic, insecticidal, ectoparasiticidal, nematicidal and acaricidal activity and also are useful intermediates for the preparation of further biologically active compounds. Compositions containing these described derivatives as active ingredients thereof are described. |
