CARBOMYCIN BIOSYNTHETIC GENE, DESIGNATED CARG, FOR USE IN STREPTOMYCES AND OTHER ORGANISMS

摘要

The carG gene of Streptomyces thermotolerans has been isolated and used to construct recombinant DNA expression vectors. The carG gene encodes the activities required for the biosynthesis of the 16-member cyclic lactone of carbomycin. The carG gene can be used not only to construct recombinant cells with an increased ability to produce carbomycin but also to construct recombinant cells with the ability to produce novel antibiotic compounds.