Aryloxymethyl derivatives of nitrogenous heterocyclic methanols and ethers thereof having cardiovascular activity.

摘要

Novel heterocyclicmethanols are disclosed having the formula: <CHEM> wherein Z is pyrrolidinyl, piperidinyl, homopiperidinyl or pyridinyl; R<1> is hydrogen, loweralkyl or carbethoxymethyl; R<2> is hydrogen, loweralkyl or cycloalkyl, phenyl or phenyl-loweralkyl; R<3> is 1 or 2-naphthalenyl, 2,3-dihydroinden-4 or 5-yl, phenyl or phenyl substituted by loweralkyl, loweralkoxy, halogen, trifluoromethyl, phenyl, methylenedioxy, nitro, amino, loweralkylamino, diloweralkylamino, loweracylamino; the 1-position of 2-pyrrolidinyl, 2-piperidinyl or 2-homopiperidinyl may be substituted by an R<4> loweralkyl group, or R<1> may form methylene or -CH2-C(O)- bridges with R<4>; the pharmaceutically acceptable salts and diastereomers thereof, which compounds have antiarrhythmic and/or hypotensive activity in animals.