| 发明名称 |
Recombinant DNA which codes for interleukin-1 B |
| 摘要 |
The subject invention concerns a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1), and fragments thereof, and the polypeptides and peptides obtained. Specifically, the subject invention comprises the cloning of a cDNA synthesized by reverse transcription of poly(A)RNA isolated from adherent human monocytes stimulated with bacterial endotoxin. Human IL-1 is useful to induce the production of IL-2 by activated T-cells; it also acts on B-cells and NK-cells.
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| 申请公布号 |
US4766069(A) |
申请公布日期 |
1988.08.23 |
| 申请号 |
US19870004319 |
申请日期 |
1987.01.08 |
| 申请人 |
NEW ENGLAND MEDICAL CENTER;TUFTS COLLEGE;WELLESLEY COLLEGE;MIT |
发明人 |
AURON, PHILIP E.;DINARELLO, CHARLES A.;WEBB, ANDREW C.;RICH, ALEXANDER;WOLFF, SHELDON M. |
| 分类号 |
A61K38/00;A61P43/00;C07K14/545;C07K14/81;C12N1/21;C12N15/25;C12N15/58;C12P21/02;C12P21/04;(IPC1-7):C12P21/02;C12P21/00;C12P19/34;C12N15/00;C12N5/00;C12N1/00;C12N1/20;C12N1/16;C12N1/18;C07H21/04 |
主分类号 |
A61K38/00 |
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