| 摘要 |
PURPOSE:To obtain the titled preparation highly releasing clonidine, improving bioavailability, capable of being administered for a long period, by using a matrix containing a specific elastic polymer, a water absorbing high polymer, natural gum substance and a higher fatty acid ester. CONSTITUTION:1-20wt.% especially 5-12wt.% clonidine is added to a matrix containing (A) 5-20wt.% elastic polymer of (A-B)nX or (A-B)n-A type [A is monovinyl-substituted aromatic compound polymer block; B is conjugated diolefin copolymer block; n is 3-7; X is residue of polyfunctional compound to which n polymer chains (A-B) are bonded] as a matrix base, (B) 1-7wt.% water absorbing high polymer such as water-soluble polymer to which a crosslinking bond of light degree is introduced, (C) 0.5-5wt.% natural gum substance preferably karaya gum or guar gum and (D) 0.1-4wt.% higher fatty acid ester as essential components.
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