CONTROLLED RELEASE SOLID DRUG DOSAGE FORMS BASED ON MIXTURES OF WATER SOLUBLE NONIONIC CELLULOSE ETHERS AND ANIONIC SURFACTANTS

摘要

A carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a controlled and prolonged release pattern upon administration, the carrier base material being a mixture of one or more nonionic cellulose ethers and an anionic surfactant, and wherein at least one of the cellulose ethers is methyl cellulose or hydroxypropylmethylcellulose having a number average molecular weight of at least 50,000.