发明名称 |
NYE RENININHIBERENDE FORBINDELSER |
摘要 |
<p>Compounds having a renin inhibitory effect and having the formula <CHEM> are disclosed wherein X is H or a N-protecting group R<1>-(CH2)n-O-C(O)- where n is O-4; R<1> is a straight or branched alkyl group containing 1-6 carbon atoms and B is phenylalanyl; O-methyltyrosyl; homophenylalanyl; cyclohexylalanyl; dibenzylacetyl and C is norvalyl; valyl; norleucyl; leucyl; histidyl; either as such or N-alkylated and R<5> is a straight or branched alkyl group containing 1-6 carbon atoms or a cyclohexylmethyl group and R<6> is H or a stright or branched alkyl group containing 1-6 carbon atoms and Y is selected from a) -SCH(CH3)2 b) -S(O)2CH(CH3)2 either as such or in the form of physiologically acceptable salts and including optical isomers. Processes for preparation and pharmaceutical preparations for such compounds and methods for treatment of heart disorders with such compounds are further disclosed.</p> |
申请公布号 |
DK469588(D0) |
申请公布日期 |
1988.08.22 |
申请号 |
DK19880004695 |
申请日期 |
1988.08.22 |
申请人 |
HAESSLE, AKTIEBOLAGET |
发明人 |
KARLSSON, JAN OLLE;SOHTELL, ERIK MORGAN HERMAN;STARKE, CARL INGEMAR;WESTERLUND, ROLF CHRISTER |
分类号 |
C07D233/64;A61K;A61K38/00;A61P9/00;A61P9/12;C07C;C07C317/28;C07C323/60;C07D;C07D263/20;C07D263/24;C07K;C07K1/02;C07K1/113;C07K5/02;C07K5/06;C07K5/065;C07K14/81;(IPC1-7):C07C147/05;C07D263/22 |
主分类号 |
C07D233/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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