PROCESS FOR PREPARING HYDROTROPIC ACIDS AND ESTERS THEREOF FROM PROPIOPHENONES

摘要

A process for preparing hydratropic acids and the esters thereof, of formula Ar-CH(CH3)-COOR where R=H or lower alkyl and Ar=phenyl possibly substituted. This process consists in reacting on the propiophenones of formula ArCOCH2CH3, a chlorinating or brominating agent, an alcohol R'OH where R'=lower alkyl, an orthoester R1-C(OR')3 wherein R1=H or lower alkyl, and metal zinc; then possibly hydrolyzing the esters obtained. With this process can be prepared hydratropic acids known for their anti-inflammatory activity.