| 发明名称 |
An arg-serpin human plasminogen activator inhibitor designated PAI-2. |
| 摘要 |
<p>A novel Arg-Serpin human plasminogen activator inhibitor, designated PAI-2, has been prepared via recombinant DNA means. Other serpins can be made by amino-acid substitutions or deletions in conserved regions of PAI-1 and PAI-2. The proteins can be used to inhibit, or at least to modulate, human plasminogen activator activity in a variety of physiological conditions, e.g. fibrinolysis, tumor metastasis and tumor growth.</p> |
| 申请公布号 |
EP0278696(A2) |
申请公布日期 |
1988.08.17 |
| 申请号 |
EP19880300986 |
申请日期 |
1988.02.05 |
| 申请人 |
NEW ENGLAND MEDICAL CENTER HOSPITALS, INC.;WELLESLEY COLLEGE |
发明人 |
WEBB, ANDREW C.;AURON, PHILIP E. |
| 分类号 |
C12N9/99;A61K38/00;C07K14/00;C07K14/545;C07K14/81;C12N1/16;C12N1/20;C12N1/21;C12N5/10;C12N15/09;C12N15/25;C12N15/58;C12P21/02;C12P21/04 |
主分类号 |
C12N9/99 |
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