| 摘要 |
PURPOSE:To obtain an agent for eliminating active oxygen in organisms, comprising a disulfide type thiamine derivative as an active ingredient. CONSTITUTION:An agent for eliminating active oxygen useful as a preventive or a remedy for diseases such as ischemic heart diseases, ischemic cerebral tissue disorder, digestive organ diseases, diabetes, inflammations, autoimmune diseases, etc., considered to be caused by active oxygen in organisms, eliminating active oxygen, especially superoxide radical, under physiological condition, comprising a disulfide type thiamine derivative such as fursulthiamine hydrochloride, thiamine disulfide (salt), bisbentiamine or bisibutiamine as an active ingredient. A dose is ordinarily 1-300mg, preferably 5-100mg calculated as disulfide thiamine derivative in the case of human oral administration and administered dividedly one time-three times.
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