发明名称 Process for preparing ceftazidime pentahydrate.
摘要 <p>An improvement in the process of preparing ceftazidime pentahydrate from ceftazidime dihydrobromide which comprises commingling a secondary-amine-type ion-exchange resin such as Amberlite LA-2 in a water-immiscible organic solvent with an aqueous solution of the dihydrobromide, stirring the mixture while maintaining a pH at or below about 6.0 and isolating ceftazidime pentahydrate from the aqueous layer. This process provides significantly higher yields of the pentahydrate than previously could be obtained from the dihydrobromide.</p>
申请公布号 EP0278656(A1) 申请公布日期 1988.08.17
申请号 EP19880300847 申请日期 1988.02.02
申请人 ELI LILLY AND COMPANY 发明人 WIRTH, DAVID DALE
分类号 C07D501/00;C07D501/46;(IPC1-7):C07D501/46 主分类号 C07D501/00
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