| 摘要 |
The present invention relates to compounds of the general formula (III) <CHEM> wherein R<1> is hydrogen when R<2> is methyl or R<1> is methyl when R<2> is hydrogen, and pharmaceutically acceptable salts thereof, i.e. the compounds 2,4-diamino-5-methyl-6-(2-hydroxy-5-methoxybenzyl)pyrido (2,3-d)pyrimidine and 2,4-diamino-5-methyl-6-(5-hydroxy-2-methoxybenzyl)pyrido(2,3-d)pyrimidine and their pharmaceutically acceptable salts. The compounds have potent inhibitory activity against dihydrofolate reductase, and are useful in treating bacterial infections and in treating proliferative diseases, for example in mammals. Compounds of formula (III) may be prepared for example by debenzylation of the corresponding benzyloxy derivative. |
