HYPOCHOLESTEROLEMICALLY ACTIVE PROTEIN

摘要

A hypocholesterolemically active protein capable of reducing the blood cholesterol in mammals having the following characteristics: (a) Molecular weight by gel filtration: 30,000+/-7,000 (b) Isoelectric point: 7.9+/-0.2 (c) Amino acid composition (mole %): -Glycine 25.23 Alanine 10.98 -Glutamate 10.34 Asparaginate 8.20 -Lysine 6.39 Leucine 5.58 -Valine 5.41 Isoleucine 5.18 -Threonine 4.23 Tyrosine 4.19 -Serine 3.46 Proline 2.62 -Arginine 2.60 Phenylalanine 2.51 -Methionine 1.56 Histidine 1.30 -Cysteine 0.16 - (d) Pattern of electrophoresis: a sharp band on the anode side on polyacrylamide gel electrophoresis. This hypocholesterolemically active protein is derived from a microorganism belonging to the genus Streptococcus.