Novel single-chain hybrid plasminogen activators having an amino acid sequence composed of at least two subsequences corresponding in amino acid identity and number to subsequences of human t-PA and of human u-PA, and mutants thereof in which at least one of the N-glycosylation sites is modified such that glycosylation cannot take place at these sites exhibit valuable pharmacological properties. The hybrid plasminogen activators are produced by recombinant DNA technology.
申请公布号
EP0277313(A1)
申请公布日期
1988.08.10
申请号
EP19870117892
申请日期
1987.12.03
申请人
CIBA-GEIGY AG
发明人
RAJPUT, BHANU, DR.;CHAUDHURI, BHABATOSH, DR.;ASSELBERGS, FREDERICUS ALPHONSUS MARIA, DR.;MEYHACK, BERND, DR.;HEIM, JUTTA, DR.;VAN OOSTRUM, JAN, DR.;ALKAN, SEFIK, PROF. DR.