发明名称 |
Ergolinyl heterocycles. |
摘要 |
<p>Ergoline derivatives of the formula I <CHEM> wherein R1 represents a hydrogen atom or a methyl group; R2 represents a hydrogen atom or a methoxy group; R3 represents a hydrocarbon group having from 1 to 4 carbon atoms; X represents a nitrogen atom and Y represents an oxygen atom, a - @-R4 or a -N=@-R5 group wherein R4 represents a hydrogen atom, a C1-C4 alkyl or a phenyl group, R5 represents a hydrogen atom, a C1-C4 alkyl, a phenyl, an amino or di(C1-C4 alkyl)amino group and the nitrogen atom of the group -N= @-R5 is not joined to the nitrogen atom represented by X, or Y represents a nitrogen atom and X represents an oxygen atom or a - @-R4 group wherein R4 is as above defined; and the pharmaceutically acceptable salt thereof; are useful for treatment of Parkinsonism and dyskinetic syndromes.</p> |
申请公布号 |
EP0277805(A1) |
申请公布日期 |
1988.08.10 |
申请号 |
EP19880300863 |
申请日期 |
1988.02.02 |
申请人 |
FARMITALIA CARLO ERBA S.R.L. |
发明人 |
BRAMBILLA, ENZO;MANTEGANI, SERGIO;PEGRASSI, LORENZO;ROSSI, ALESSANDRO;TEMPERILLI, ALDEMIO |
分类号 |
C07D457/02;A61K31/48;A61P25/00;C07D457/00;(IPC1-7):C07D457/00 |
主分类号 |
C07D457/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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