| 摘要 |
Antihypertensive phosphate derivatives having the following formula are described: <IMAGE> wherein X is selected from one or more of: (a) C1-C24 branched or straight chain alkyl; (b) C1-C24 branched or straight chain alkoxy; (c) <IMAGE> <IMAGE> <IMAGE> <IMAGE> wherein n and m are integers from 0 to 25 and the sum of n and m is less than or equal to 25; phenyl; substituted phenyl wherein the substituents are selected from the group consisting of C1-C20 branched or straight chain alkyl, C1-C20 branched or straight chain alkoxy, halogen, trifluoromethyl, phenyl, and substituted phenyl, phenoxy; and substituted phenoxy, wherein the substituents are selected from the group consisting of C1-C20 branched or straight chain alkyl, halogen, trifluoromethyl, phenyl and substituted phenyl; Q is selected from the group consisting of: <IMAGE> wherein R1 is selected from the group consisting of hydrogen, C1-C4 branched or straight chain alkyl, C1-C4 branched or straight chain alkoxy and C1-C4 branched or straight chain alkylamino and wherein R3 is C1-C4 alkyl, with the proviso that when Q is <IMAGE> then R1 is C1-C4 branched or straight chain alkyl; T is a bivalent radical selected from the group consisting of -(CHR)p- and <IMAGE> wherein p is an integer from 1 to 15, the moiety -(CHR)p- represents an alkylene chain substituted at any position with one or more C1-C10 alkyl groups or phenyl groups, and the moiety <IMAGE> is bound with the oxygen atom attached directly to the aromatic ring; and Z is <IMAGE> wherein R2 is hydrogen or C1-C4 branched or straight chain alkyl and q is an interger from 4 to 7; in either the racemic or optically active forms.
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