| 摘要 |
PURPOSE:To obtain the titled compound useful as a synthetic intermediate for an antiulcer agent, cimetidine, at a low cost, without forming stenchy methyl mercaptan, by using cystamine as a raw material and reacting with an isothiourea derivative under basic condition. CONSTITUTION:The objective compound of formula III can be produced by reacting cystamine of formula I or its salt with an isothiourea derivative of formula II (R is lower alkyl) under basic condition (e.g. with sodium hydroxide) in a solvent (e.g. water, methanol, etc.) at 20-120 deg.C, preferably 60-100 deg.C. The amounts of the compound of formula I and the base are 0.4-2mol. (preferably 0.5-0.7mol.) and 0.8-5mol. (preferably 1-3mol.) per 1mol. of the compound of formula II, respectively, and that of the solvent is 2-50pts.wt. (preferably 5-30pts.wt.) per 1pt.wt. of the compound of formula II. The compound of formula II is derived from dimethylcyanodithioimide carbonate and a primary aliphatic amine.
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