| 摘要 |
NEW MATERIAL:14-Hydroxy-6-0-methylerythromycin B expressed by formula I and salts thereof. USE:Useful as an antibiotic substance capable of exhibiting antimicrobial activity against part of Gram-positive bacteria, particularly Staphylococcus aureus, Staphylococcus epidermis, Enterococcus faecalis, Micrococcus luteus and Bacillus subtilis. PREPARATION:A mold, preferably a fungus belonging to the genus Mucor, Cunninghamella or Beauveria, e.g. Mucor circinelloides f. griseo-cyanus IFO 4563, etc., is cultivated in a culture medium containing 6-O-methylerythromycin B expressed by formula II as a substrate, preferably at 28-30 deg.C and pH 7-8 for 3-7 days. |
