| 摘要 |
NEW MATERIAL:A compound shown by formula I [R<1> is H or amino-protecting group, R<2> and R<3> are H, OH-protecting group or R<2> and R<3> are bonded to form isopropylidene; R<4> and R<5> are H or carboxy-protecting group; R<6> is H, OH, amino, hydroxysulfonyl, etc.; R<7> is H, methyl, (protected) carboxyl, etc.; wavy line is anti form or syn-form bond], a salt, a hydrate or a salt hydrate thereof. EXAMPLE:( 6R,7R )-7-[ 2-( 2-Amino-4-thiazolyl )-2-[ Z-[( 3-carboxy-4,5- dihydroxyphenyl )methyl ]oxyimino]acetamido ]-3-[( 2-carboxy-5-methyl- s-triazole[ 1,5-a ]pyrimidin-7-yl )thiomethyl ]-8-oxo-5-thia-1-azabicyclo[ 4,2,0 ]oct-2-ene-carboxylic acid. USE:An antibacterial agent against Gram-positive and Gram-positive bacteria, having high safety. PREPARATION:A compound shown by formula II is reacted with a compound shown by formula III. |
