| 摘要 |
PURPOSE:To obtain a bundle-shaped collective crystal having good releasability from a cooing face and good solid-solution separating property in filtration and dehydration, by cooling aqueous solution of L-alpha-aspartyl-L-phenylalanine methyl ester (APM) by conduction and heat transfer without giving forced flow such as a mechanical stirring, etc., to the solution to provide pseudo-solid phase and as necessary further cooling the solution. CONSTITUTION:An aqueous solution of L-alpha-aspartyl-L-phenyl alanine methyl ester (APM) having initial concentration set so that the deposited solid phase after cooling is >=10g based on 1l solvent is cooled by conduction and heat transfer without giving forced flow such as a mechanical stirring etc., to the solution to form sherbet-like pseudo-solidifying phase apparently in whole the solution, which is, an necessary, further cooled to provide the aimed collective crystal having 3-4cc/g static specific volume and 2-3cc/g dense specific volume.
|
