发明名称 |
METHOD OF INACTIVATING REPRODUCIBLE FILTERABLE PATHOGENS INBLOOD PRODUCTS AS WELL AS A METHOD OF PRODUCING BLOOD PRODUCTS |
摘要 |
<p>A method of inactivating viruses in blood products is described, wherein the blood products are heat-treated in a humid or in a solid state in the presence of inorganic or organic hydroxyl group-containing compounds having an H+dissociation constant of < 10-11 in a concentration of more than 0.05 (5 % by weight) and less than 0.70 (70 % by weight). The hydroxyl group-containing compounds may be water, methanol, or ethanol. The temperature may amount up to 121.degree.C, the heat treatment may last from 1 s to 100 h. The inactivation method may be applied for producing blood products selected from enzymes, proenzymes including coagulation factors, enzyme inhibitors, immunoglobulins, albumin, plasminogen, fibrinogen, fibronectin or plasma, the inactivation destroying any reproducible filterable pathogens that might be present.</p> |
申请公布号 |
CA1239583(A) |
申请公布日期 |
1988.07.26 |
申请号 |
CA19850475883 |
申请日期 |
1985.03.07 |
申请人 |
IMMUNO AKTIENGESELLSCHAFT FUER CHEMISCH-MEDIZINISCHE PRODUKTE |
发明人 |
EIBL, JOHANN;SCHWARZ, OTTO;ELSINGER, FRIEDRICH;WOEBER, GUENTER;PHILAPITSCH, ANTON;LINNAU, YENDRA;DORNER, FRIEDRICH;TRAMBAUER, KARL;FRECHINGER, WOLFGANG |
分类号 |
A61K39/395;A61K35/14;A61K35/16;A61K38/16;A61K38/48;A61K38/55;A61L2/00;A61L2/04;C12N9/68;(IPC1-7):A61L2/04 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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