发明名称 |
GLUCOSAMINE-PEPTIDE DERIVATIVES, THEIR PRODUCTION AND USE |
摘要 |
<p>Novel glucosamine-peptide derivatives of the formula: wherein m is 0 or 1; n is 0 or an interger of 1 to 9; R is lower alkyl which may be substituted with hydroxyl, or aryl; R1 is hydrogen or acyl having an acyclic hydrocarbon group, the terminal of which may be substituted with a cyclic hydrocarbon group directly, via a carbonyl group or via an oxygen atom; provided that when R1 is hydrogen m is 1; R2 is hydrogen or lower alkyl which may form a ring by connecting its terminal with the .alpha.-nitrogen atom when n is 0, or hydrogen when n is an interger of 1 to 9; R3 is hydrogen or lower alkyl; R4 and R5 are each hydrogen or lower alkyl which may be substituted with hydroxyl or benzyloxyl; R6 is hydrogen or lower alkyl; R7 is alkyl which may be substituted with lower alkoxyl or aralkyl; R8 is hydrogen or lower alkyl; R9 is hydrogen, lower alkyl or aralkyl; and (D) and (L) each indicate configurations if their respective carbon atoms are asymmetric; or an acid addition salt thereof, have immunostimulatory activity.</p> |
申请公布号 |
CA1239636(A) |
申请公布日期 |
1988.07.26 |
申请号 |
CA19800346133 |
申请日期 |
1980.02.21 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
YAMAMURA, YUICHI;AZUMA, ICHIRO;KOBAYASHI, SHIGERU |
分类号 |
A61K31/70;A61K31/7024;A61K31/7028;A61K38/00;A61K39/39;A61P35/00;A61P37/00;A61P37/04;C07H13/04;C07H13/08;C07H15/04;C07H15/18;C07K1/113;C07K9/00;(IPC1-7):C07K9/00 |
主分类号 |
A61K31/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|