2-QUATERNARY AMMONIO PENEM DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENT

摘要

New antibacterial agents are compounds of formula …… wherein R is hydrogen atom or C1-C4 alkyl group optionally substituted from halogen atom or hydroxy group optionally protected, A is Z, ZOCO or ZCO residue, wherein Z is phenylene, naphthylene, heterocyclediyl, C1-C7 alkylene, C2-C4 alkenylene, alkynylene, ……, C3-C8 cycloalkylene, aralkylene radical optionally substituted, and Q<(+)> represents a group ……, wherein R1, R2 and R3 are each either: … …  (i) optionally substituted alkyl, aralkyl or aryl radical or …  (ii) R1 is as defined above under (i) and R2, R3, taken together, represent an optionally substituted or fused heterocyclic radical or …  (iii) R1, R2, R3 taken together, represent an optionally substituted azonia-bicyclo or tricyclo radical or …  (iv) R1, R2, R3, taken together, represent an optionally substituted or fused pyridinium, pyrazinium, pyrazolium or pyridazinium radical, and the pharmaceutically or veterinarily acceptable salts thereof. … …The compounds are prepared by reacting the amine NR, R<2> R<3> with the corresponding penem substituted in the s positions by A-HC2-L group where A is as defined above and L is a leaving group.