PLASMIDS AND MODIFIED STRAINS OF VIBRIO CHOLERAE, THEIR PREPARATION AND DERIVED VACCINES

摘要

Plasmids and modified strains of Vibrio cholerae are prepared which are a genetically stable nontoxinogenic form of Vibrio cholerae which has a deletion mutation in both copies of the A1-peptide-encoding gene, resulting in the loss of a gene sequence required for expression of a toxic A1 peptide. The modified strains are useful as live or dead oral vaccines.