| 发明名称 |
Novel peptidase inhibitors. |
| 摘要 |
<p>This invention relates to activated electrophilic ketone retroamide analogs of certain peptidase substrates having the formula R1NHCHR2COCF2CHR3(NRbCOXRa)nQ These compounds are useful in inhibiting serine-, thiol-, carboxylic acid- and metallo- dependent proteolytic enzymes, the inhibition of which will have useful physiological consequences in a variety of disease states.</p> |
| 申请公布号 |
EP0275101(A2) |
申请公布日期 |
1988.07.20 |
| 申请号 |
EP19880100452 |
申请日期 |
1988.01.14 |
| 申请人 |
MERRELL DOW PHARMACEUTICALS INC. |
发明人 |
SCHIRLIN, DANIEL;JUNG, MICHEL |
| 分类号 |
C07C271/20;C07C271/22;C07C271/28;C07C279/18;C07C279/24;(IPC1-7):C07K5/02;C07C103/82;C07C125/06;C07K1/00;C07C103/44 |
主分类号 |
C07C271/20 |
| 代理机构 |
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代理人 |
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| 地址 |
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