| 摘要 |
PURPOSE:To obtain a stable aqueous composition useful as an antimicrobial agent with hardly any irritancy, by adding a polyhydric alcohol or boric acid to isotonize quinolonecarboxylic acids and adjusting the pH to a given value. CONSTITUTION:The aimed substance obtained by adding a polyhydric alcohol, e.g. glycerol, or boric acid to isotonize a compound expressed by the formula or a salt thereof, then adjusting the pH to 3-6.5, if necessary, blending an additive, e.g. buffering agent of pH adjuster, preservative germicide, chelating agent, etc., and preparing a pharmaceutical by a conventional method. The concentration of the compound expressed by the formula is about 0.01-10% based on the total amount and the polyhydric alcohol and boric acid are contained in amounts as follows, e.g. about 1.9% boric acid, about 2.6% glycerol, about 5.1% mannitol and about 5.1% glucose. The compound expressed by the formula having a wide antimicrobial spectrum against Gram-positive and Gram-negative bacteria is used as an injection, ear drop, nasal drop and eye drop for medical applications.
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