PROCESS FOR PREPARATING NEW THEOPHYLINE DERIVATIVES

摘要

Novel theophylline derivs. of formula (I) and its pharmaceutically acceptable acid addn. salts are prepd. by reacting 7-substd. theophylline (by -CH2-(CH)n(R)-CH2-Hal) with (II). R=H or hydroxyl, n=0 or 1, X= =CH or =N-, Y= -O- or =C=O, Ar=opt. substd. -unsatd. five or six membered carbocyclic or heterocyclic ring, Hal=Cl or Br. Novel compds. (I) are e.g. esp. 7-[2-[4-(ptollyloxy)-piperidino - ethyl -theophylline (Sgd 94-78) and 7-[2-[4-(p-fluorobenzoyl)- piperidino -ethyl -theophylline (Sgd 195-78).