| 摘要 |
PURPOSE:To obtain an essentially transparent or semi-transparent soft capsule having improved light-stability of drug contained therein, by covering an oily solution containing a light-unstable drug with a capsule skin containing specific fine particles of titanium oxide. CONSTITUTION:A solution containing a light-unstable drug is covered with a capsule skin (a combination of gelatin, glycerol and various preservatives) containing fine particles of titanium oxide having a maximum particle diameter of <=0.1mum and an average particle diameter of 0.01-0.07mum. Particles having diameter of <=0.1mum account for at least 85% of the whole particles. The amount of the titanium oxide fine particle is >=0.001wt.%, preferably 0.01-5wt.% based on the total amount of the constituent components for the capsule skin.
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