发明名称 |
Glycosylated glycopeptides. |
摘要 |
Gylcosylated glycopeptide antibiotics having the formula I <CHEM> in which A is the remaining portion of a glycopeptide antibiotic of the vancomycin/ristocetin class or a chemical derivative thereof, and O is the phenolic oxygen of the central (B) ring of the triaryl ether region of the glycopeptide antibiotic; and R is a monosaccharide or disaccharide or a deoxy or amino variant thereof; provided that R is not the natural sugar species attached at this site on the glycopeptide core, and R is not glucosyl when A is the remaining portion of vancomycin, A51568A, M43D, or A51568B and their salts are useful new antibiotics. A process for producing compounds of formula (I) or a chemical derivative thereof, or a pharmaceutically acceptable salt thereof. These derivatives are useful for treating or preventing infection in an animal by gram-positive bacteria and also increase feed-utilization efficiency, promote growth in domestic animals and increase propionate production in lactating ruminants. |
申请公布号 |
EP0273727(A2) |
申请公布日期 |
1988.07.06 |
申请号 |
EP19870311421 |
申请日期 |
1987.12.23 |
申请人 |
SMITHKLINE BECKMAN CORPORATION |
发明人 |
CHRISTENSEN IV, SIEGFRIED BENJAMIN;CHUNG, SUNG KEE;JEFFS, PETER WALTER |
分类号 |
A23K1/17;A23K1/18;A61K38/00;A61P31/04;C07K1/02;C07K1/113;C07K9/00 |
主分类号 |
A23K1/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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