| 摘要 |
PURPOSE:To obtain a remedy for osteoporosis having strong bone-resorption suppressing action and osteogenesis promoting action and high safety, by using a 2-phenyl-4H-1-benzopyran-4-one derivative as an active component. CONSTITUTION:The objective agent can be produced by mixing a compound of formula I (R<1> and R<2> are H or 1-3C alkyl) or its salt with conventional pharmqaceutical additives such as vehicle, disintegrator, binder, etc., and forming the mixture in the form of a drug according to conventional method. It is administered at a dose of 10-1,000mg/day for adult by oral administration in the form of tablet, powder, capsule, etc., or 1-100mg/day for adult by parenteral. administration in the form of injection, etc. The compound of formula I can be produced by reacting an acetophenone derivative of formula II with benzoyl chloride and subjecting the product to Baker-Venkataraman rearrangement and dehydrative cyclization.
|
