Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors.

摘要

Thiol protease inhibitors are disclosed having the formula: or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein: n is 0 or 1; m is 0, 1 or 2; X is H or an N-protecting group; each Y is independently an optionally protected alpha -amino acid residue; R is an optionally protected alpha -amino acid side chain that is H or CH3 or that is bonded to the alpha -carbon atom to which it is attached by a methylene, methine or phenyl radical; and R' is optionally substituted aryl.