摘要 |
Optically active compounds of the formula <CHEM> or a salt thereof wherein R1 is H or lower alkyl; R2 and R6 are each independently lower alkyl, aryl, or arylalkyl; R3 is CN, NO2, CO2R5, CONHR5, SO2R5, or P(O)(OR5)2, where R5 is lower alkyl, lower alkoxyalkyl, aryl, or arylalkyl; R4 is aryl, heterocyclyl, or fused-ring heterocyclyl, optionally substituted with one, two, or three halo, NO2, CN, lower alkyl, lower alkoxy, lower alkylamino, CF3, OCH2F, or OCF3; are formed from a salt mixture of the compound with a resolving agent in a hot solvent mixture of an organic solvent and water. |