发明名称 |
Transdermal flux enhancing compositions. |
摘要 |
<p>A transdermal flux enhancing pharmaceutical composition for transdermal administration to a human or lower animal subject comprising a safe and effective amount of a pharmacologically active compound or a prodrug thereof, an aqueous ethanol solvent containing from 15 to 75% ethanol by volume, and a penetration enhancer selected from certain 1-alkylazacycloheptan-2-ones and cis-olefin compounds of the formula CH3(CH2)xCH=CH(CH2)yR<3> where R<3> is CH2OH, CH2NH2 or COR<4> and R<4> is OH or (C1-C4)alkoxy, x and y are each an integer from 3 to 13 and the sum of x and y is from 10 to 16; methods for their use in treating various illnesses in a human or lower animal by transdermal administration of said composition.</p> |
申请公布号 |
EP0271983(A1) |
申请公布日期 |
1988.06.22 |
申请号 |
EP19870309459 |
申请日期 |
1987.10.27 |
申请人 |
PFIZER INC. |
发明人 |
FRANCOEUR, MICHAEL LEE;POTTS, RUSSELL OWEN |
分类号 |
A61K31/54;A61K9/06;A61K9/08;A61K31/60;A61K47/00;A61K47/10;A61K47/12;A61K47/14;A61K47/16;A61K47/18;A61K47/22;A61P17/00;(IPC1-7):A61K47/00 |
主分类号 |
A61K31/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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