| 摘要 |
NEW MATERIAL:A compound (salt) shown by formula I [A is group shown by formula II (R1 and R2 are alkyl, substituted alkyl, cycloalkyl, aralkyl, etc.), morpholino, etc.; Ra and Rb are H or methyl; X is O or S; m is 2-8 integer; n is 0 or 1]. EXAMPLE:7-N-(2-Methylaminocarbonylthioethyl)mitomycin C. USE:An antitumor agent. PREPARATION:For example, an amine compound shown by the formula AH is reacted with a halocarbonic acid ester to give a carbamic acid haloalkyl ester shown by formula III (Hal is halogen), which is reacted with a mercaptoalkylamine to give a compound shown by formula IV. Then this compound is reacted with a 7-methoxymitomycin shown by formula V to give a compound shown by formula I.
|
