发明名称 |
Thrombin aerosol |
摘要 |
A process is disclosed for delivery thrombin in dry powdered form from an aerosol container by first lyophilizing an aqueous solution of thrombin and a thrombin-compatible synthetic polymer e.g. polyvinyl pyrrolidone, placing the lyophilized cake in a pressure bottle by crimping on a valve stem and top, filling liquified chlorofluoroalkane-containing aerosol propellant into the bottle, and actuating the valve to dispense in dry-finely divided powdered form a mixture of thrombin and polyvinyl pyrrolidone, which powdered thrombin is for use in controlling bleeding during surgery.
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申请公布号 |
US4752466(A) |
申请公布日期 |
1988.06.21 |
申请号 |
US19870091165 |
申请日期 |
1987.08.31 |
申请人 |
JOHNSON & JOHNSON PRODUCTS, INC. |
发明人 |
SAFERSTEIN, LOWELL;WOLF, STEPHEN J. |
分类号 |
A61K9/12;A61K38/00;A61L24/00;A61L26/00;C12N9/74;(IPC1-7):A61K9/14;A61K35/14;A61K37/00 |
主分类号 |
A61K9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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