| 摘要 |
PURPOSE:To produce an optically active phenylalanine derivative useful as medicines, agricultural chemicals, antimicrobial agents, reagents and intermediate raw materials therefor, by hydrolyzing a specific fluorine-containing compound with aminoacylase. CONSTITUTION:A fluorine-containing compound expressed by formula I [X and Y are integers of 0-3 (X + Y <=3); m and n are integers of 0-5 (m + n <=5)], preferably N-acetyl-trifluoromethyl-(DL)-phenylalanine or N-acetyl- pentafluoro-(DL)-phenylalanine is preferably brought into contact with aminoacylase derived from the genus Aspergillus and converted into a compound expressed by formula II. The resultant L-isomer fluorine-containing phenylalanine formed by the hydrolytic reaction of the above-mentioned enzyme is purified by an ion exchange resin and N-acetyl-(DL)-fluorine-containing phenylalanine remaining in the reaction solution is racemized with acetic anhydride and then as DL-isomer reused for acylase reaction.
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