| 摘要 |
PURPOSE:To readily obtain the titled diol useful as a key compound for asymmetric reaction, etc., in high asymmetric selectivity, by hydrolyzing a lower fatty acid diester of racemic binaphthol with lipase. CONSTITUTION:(A) A lower fatty acid diester of 1,1'-binaphthyl-2,2'-diol, e.g. a compound expressed by formula I, etc., is hydrolyzed with (B) lipase to afford the aimed diol, e.g. a compound expressed by formula II, etc. The above- mentioned lower fatty acid is preferably a 2-6C lower fatty acid and lipase is preferably porcine pancreatic lipase. The hydrolysis is preferably carried out in a two-phase system of an organic phase containing a substrate dissolved in an organic solvent and a phosphoric acid buffer solution.
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