| 摘要 |
NEW MATERIAL:The compound of formula I [at least one of R<1>-R<4> is higher alkanoylamino, higher alkenylamino, higher alkoxycarbonylamino, higher alkylaminocarboxylamino, higher alkoxy(lower)alkanoylamino or higher alkylthiocarbonylamino which may have substituent group and the others are amino or acylamino; Ra<5>-Ra<9> are acyloxy; R<10>' is OH, acyloxy, ar(lower)alkoxy or protected phosphonoxy]. EXAMPLE:1,3,6'-Tris-N-benzyloxycarbonyl-3''-N-trifluoroacetylkanamycin A. USE:Antiviral agent, immunoactivation agent and their production raw material. PREPARATION:The compound of formula III (Ra<10>' is acyloxy) can be produced e.g. by reacting a compound of formula II with a proper acylation agent in a solvent such as THF in the presence of a base such as triethylamine.
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