ENHANCING GAMMA-CARBOXYLATION OF RECOMBINANT VITAMIN K-DEPENDENT PROTEINS

摘要

A DNA sequence including a first DNA sequence encoding a human vitamin K-dependent protein having fused to its 5' end a second DNA sequence not identical to the propeptide encoding sequence naturally associated with the DNA sequence encoding the protein, the non-naturally occuring propeptide encoding sequence being capable of encoding a propeptide which is capable of enhancing the gamma-carboxylation of the protein when the protein is expressed in a recombinant eukaryotic cell.